Preventive nutritional supplementation with furan fatty acid in a DIO mouse model increases muscle mass and reduces metabolic disorders - Institut Agro Montpellier Accéder directement au contenu
Article Dans Une Revue Biomedicine and Pharmacotherapy Année : 2023

Preventive nutritional supplementation with furan fatty acid in a DIO mouse model increases muscle mass and reduces metabolic disorders

Béatrice Bonafos
  • Fonction : Auteur
  • PersonId : 1207246
Laurent Vaysse
  • Fonction : Auteur
  • PersonId : 976161
Sylvie Gaillet
Laurence Pessemesse
  • Fonction : Auteur
  • PersonId : 1079744
Charles Coudray

Résumé

The increase in obesity has become a major global health problem and is associated with numerous metabolic dysfunctions. Furan fatty acids (FuFAs) are minor lipids present in our diet. Recently we showed that FuFA-F2 extracted from Hevea brasiliensis latex stimulates muscle anabolism in mice in vitro and in vivo, mimicking in part physical activity. While skeletal muscle is essential for energy metabolism and is the predominant site of insulin-mediated glucose uptake in the post prandial state, our results suggested that FuFA-F2 could have favorable effects against obesity. The aim of this work was therefore to study whether a preventive nutritional supplementation with FuFA-F2 (40 mg or 110 mg/day/kg of body weight) in a diet-induced obesity (DIO) mouse model may have beneficial effects against obesity and liver and skeletal muscle metabolic dysfunction. We showed that 12 weeks of FuFA-F2 supplementation in DIO mice decreased fat mass, increased lean mass and restored normal energy expenditure. In addition, we found that FuFA-F2 improved insulin sensitivity. We revealed that FuFA-F2 increased muscle mass but had no effect on mitochondrial function and oxidative stress in skeletal muscle. Furthermore, we observed that FuFA-F2 supplementation reduced liver steatosis without impact on mitochondrial function and oxidative stress in liver. Our findings demonstrated for the first time that a preventive nutritional supplementation with a furan fatty acid in DIO mice reduced metabolic disorders and was able to mimic partly the positive effects of physical activity. This study highlights that nutritional FuFA-F2 supplementation could be an effective approach to treat obesity and metabolic syndrome.
Fichier principal
Vignette du fichier
2023 Dore et al., Preventive nutritional.pdf (912.82 Ko) Télécharger le fichier
Origine : Fichiers produits par l'(les) auteur(s)

Dates et versions

hal-04114554 , version 1 (02-06-2023)

Licence

Paternité

Identifiants

Citer

Laetitia Dore, Erwann Durand, Béatrice Bonafos, Jatuporn Chaiyut, Laurent Vaysse, et al.. Preventive nutritional supplementation with furan fatty acid in a DIO mouse model increases muscle mass and reduces metabolic disorders. Biomedicine and Pharmacotherapy, 2023, 164, pp.114945. ⟨10.1016/j.biopha.2023.114945⟩. ⟨hal-04114554⟩
38 Consultations
27 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More